Friedel-Crafts Alkylation of Alkenes: Ethylaluminum Sesquichloride Induced Alkylations with Alkyl Chloroformates.
نویسندگان
چکیده
The formal addition of propane to nonactivated double bonds can be achieved with isopropyl chloroformate (2) in the presence of Et(3)Al(2)Cl(3). Thus, a 1:1 mixture of 10-isopropyloctadecanoic acid (3) and the 9-regioisomer is formed from oleic acid (1). The reaction may also be carried out with 1-alkenes by the addition of triethylsilane as a hydride donor.
منابع مشابه
Alkylation of alkenes: ethylaluminum sesquichloride-mediated hydro-alkyl additions with alkyl chloroformates and di-tert-butylpyrocarbonate.
A general method for the hydro-alkyl addition to the nonactivated C=C double bond of alkenes using alkyl chloroformates (primary, secondary), 12, and di-tert-butylpyrocarbonate, 52, mediated by ethylaluminum sesquichloride (Et(3)Al(2)Cl(3)) has been developed. Reaction of 12 and 52, respectively, with Et(3)Al(2)Cl(3) gives an alkyl cation which is added to the alkene; hydride transfer to the ad...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 38 24 شماره
صفحات -
تاریخ انتشار 1999